The compound you provided is **a potent and selective inhibitor of the enzyme HDAC6**, which is a histone deacetylase.
Here's why it's important for research:
* **HDAC6 is a key enzyme in the regulation of protein degradation and cellular stress responses**. Inhibiting HDAC6 can have various beneficial effects, including:
* **Protection against neurodegenerative diseases**: HDAC6 is implicated in Alzheimer's and Parkinson's diseases. Inhibitor compounds like the one you mentioned might be useful for developing therapeutic strategies.
* **Cancer therapy**: HDAC6 inhibitors have shown promise in reducing tumor growth and promoting apoptosis (programmed cell death) in cancer cells.
* **Treatment of inflammatory diseases**: HDAC6 inhibitors might be useful for treating inflammatory diseases by modulating the immune response.
* **Understanding the mechanism of HDAC6 inhibition**: Researchers study the interactions of these inhibitors with HDAC6 to understand the enzyme's structure and function at a molecular level. This knowledge can be used to design even more potent and specific inhibitors.
* **Drug development**: Inhibitors like this serve as lead compounds for the development of new drugs targeting HDAC6. They undergo further modifications and optimization to improve their efficacy, bioavailability, and safety.
**However, it's important to note:**
* The compound you provided is a **research tool** and not yet a clinically approved drug.
* Extensive studies are needed to ensure its safety and efficacy in humans before it can be used in medicine.
Overall, this compound is a valuable research tool with potential therapeutic implications in various diseases. It contributes to our understanding of HDAC6 and its role in various biological processes, and it paves the way for the development of new drug therapies.
ID Source | ID |
---|---|
PubMed CID | 4634206 |
CHEMBL ID | 1544116 |
CHEBI ID | 107206 |
Synonym |
---|
MLS000517184 |
smr000343335 |
CHEBI:107206 |
HMS2693P12 |
2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-n'-[2-(2-ethoxyphenoxy)acetyl]acetohydrazide |
AB00607495-06 |
Z27816581 |
CHEMBL1544116 |
2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-n'-[2-(2-ethoxyphenoxy)-1-oxoethyl]acetohydrazide |
Q27185270 |
AKOS034028555 |
Class | Description |
---|---|
oxopurine | |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 19.9526 | 0.7079 | 12.1943 | 39.8107 | AID720542 |
aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 7.5123 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
vasopressin V1b receptor | Homo sapiens (human) | Potency | 30.8810 | 0.1944 | 16.0180 | 43.6206 | AID492948 |
chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 0.0060 | 26.1688 | 89.1251 | AID540317 |
DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 0.0501 | 27.0736 | 89.1251 | AID588590 |
relaxin receptor 1 isoform 1 | Homo sapiens (human) | Potency | 28.5979 | 0.0388 | 14.3501 | 43.6206 | AID2676; AID489012; AID492949 |
relaxin receptor 2 isoform 1 | Homo sapiens (human) | Potency | 21.8621 | 0.0488 | 15.9801 | 48.9431 | AID489043 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |